白细胞介素是一类由各种白细胞产生的,介导细胞之间相互作用,参与免疫调节和炎症过程的细胞因子。本文就牙周病进展过程中牙周局部白介素水平变化作一综述。1白细胞介素-1(IL-1)Gowen等首次报告IL-1参与溶骨过程。此后大量研究表明牙周病灶组织中IL-1活性高于健康牙周组织,IL-1β水平的升高远较IL-1α明显。ELISA法检测中、重度牙周炎患者GCF中IL-1 o和IL-1β,发现IL-1β的检出率为 Interleukins are a class of cytokines produced by various leukocytes that mediate cell-cell interactions, participate in immune regulation and inflammation. This article reviews the changes of periodontal interleukin levels during the development of periodontal disease. 1 Interleukin-1 (IL-1) Gowen et al. First reported IL-1 involved in osteolytic process. Since then a large number of studies have shown that IL-1 activity in periodontal lesions higher than healthy periodontal tissue, IL-1β levels increased significantly more than IL-1α. ELISA detection of GCF in patients with moderate and severe periodontitis IL-1 o and IL-1β, found IL-1β detection rate was