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核因子κB(NF-κB)通过促进细胞因子、活性氧簇和Fas相关基因的表达介导的β细胞凋亡,可以诱发1型糖尿病。阻断依赖NF-κB的信号通路,对抗β细胞凋亡,能为糖尿病(特别是1型糖尿病)的防治提供新的手段。
Nuclear factor κB (NF-κB) can induce type 1 diabetes by promoting β-cell apoptosis mediated by the expression of cytokines, reactive oxygen species and Fas-related genes. Blocking the NF-κB-dependent signaling pathway against β-cell apoptosis can provide new tools for the prevention and treatment of diabetes, especially type 1 diabetes.