人类肿瘤可以产生一类不见于正常分化细胞的抗原成份,并可自肿瘤释放入外周血、尿液和其他体液内。 Ha11等首先报告正常人、实体瘤、良性肿瘤以及膀胱癌患者尿内可检出癌胚抗原(CEA),尤其在膀胱癌的阳性率及浓度均较高。利用兔抗血清作补体结合试验。Gozzo等发现在膀胱癌尿中还有另一种不同于CEA的抗原成份。尿路外的肿瘤同样在尿中排泄抗原。文献证实多种癌、肉瘤、黑色素瘤及实体瘤病人尿中均存在肿瘤相关抗原,但这种情况极少见于正常人。当肿瘤切除后,尿内不再有这类抗原排泄。长期随访,常可于临床诊断肿瘤复发之前发现肿瘤相关抗原的增高。作者检测了Utah大学妇癌科各种妇科恶性肿 Human tumors can produce a class of antigen components that are not found in normal differentiated cells and can be released from tumors into peripheral blood, urine, and other body fluids. Ha11 first reported in normal urine, solid tumors, benign tumors and bladder cancer in patients with detectable carcinoembryonic antigen (CEA), especially in bladder cancer positive rate and concentration were higher. Rabbit antisera was used as complement fixation test. Gozzo and other found in urinary bladder cancer there is another different from the antigen components of CEA. Urothelial tumors also excrete antigens in the urine. Literature confirmed that a variety of cancer, sarcoma, melanoma and solid tumor patients with tumor-associated antigen in urine, but rarely seen in normal cases. When the tumor is resected, no such antigens are excreted in the urine. Long-term follow-up, often in the clinical diagnosis of tumor recurrence before the discovery of tumor-associated antigen increased. The authors examined a variety of gynecologic malignancies at the University of Utah’s Department of Gynecology