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WR_(228258)的结构类似于氨酚喹,WR_(194965)的结构类似于4-氨基喹啉,WR_(225448)是一种新的8-氨基喹啉类化合物。本文报告了这三种化合物对伯氏疟原虫敏感株和几种抗性株原虫感染小鼠的裂殖体杀灭作用以及对约氏疟原虫尼日利亚株感染小鼠所产生的病因性预防作用。
The structure of WR_ (228258) is similar to paracetamol, the structure of WR_ (194965) is similar to that of 4-aminoquinoline, and WR_ (225448) is a novel 8-aminoquinoline compound. This article reports the killing effect of these three compounds on the schizont and the pathogenicity of the Nipponbare-infected Nippon Yeasts in mice infected with Plasmodium berghei and several resistant protozoa.