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目的:观察丹红注射液联合常规西药治疗2型糖尿病肾病患者的临床效果。方法:选取80例2型糖尿病肾病患者作为研究对象,按照随机数字表法分为观察组与对照组各40例,对照组给予常规治疗,观察组在常规治疗基础上给予丹红注射液治疗,2组均治疗1月。比较2组患者的临床疗效与治疗前后24h尿蛋白定量、血脂指标、血液流变学指标的变化情况。结果:治疗后,观察组总有效率为92.5%,对照组总有效率为77.5%,2组比较,差异有统计学意义(P<0.05)。2组24h尿蛋白定量、甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均较治疗前降低,高密度脂蛋白胆固醇水平均较治疗前升高,差异均有统计学意义(P<0.05);观察组24h尿蛋白定量、甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异均有统计学意义(P<0.05)。2组血液流变学指标全血黏度(高切、低切)、血浆比黏度、红细胞压积、血浆纤维蛋白原均较治疗前降低(P<0.05),观察组各项指标均低于对照组(P<0.05)。结论:丹红注射液联合常规西药治疗2型糖尿病肾病具有良好临床疗效,不仅能够延缓或者逆转肾脏损害的发展进程,还可对肾脏起到一定的保护作用,效果确切
Objective: To observe the clinical effects of Danhong injection combined with conventional western medicine in the treatment of type 2 diabetic nephropathy. Methods: Eighty patients with type 2 diabetic nephropathy were selected as study objects. According to the random number table, 40 cases were divided into observation group and control group. The control group was given routine treatment. The observation group was given Danhong injection on the basis of routine treatment. 2 groups were treated in January. The clinical curative effect and the changes of 24 h urinary protein, blood lipid and hemorheology indexes before and after treatment were compared between the two groups. Results: After treatment, the total effective rate was 92.5% in the observation group and 77.5% in the control group. There was significant difference between the two groups (P <0.05). The levels of 24h urinary protein, triglyceride, total cholesterol and low density lipoprotein cholesterol in two groups were lower than before treatment and the levels of high density lipoprotein cholesterol were higher than those before treatment (all P <0.05) ; 24h urinary protein in the observation group, triglyceride, total cholesterol, low density lipoprotein cholesterol levels were lower than the control group, high-density lipoprotein cholesterol levels were higher than the control group, the difference was statistically significant (P <0.05). The indexes of hemorheology in the two groups were lower than those before treatment (P <0.05), the whole blood viscosity (high and low cut), plasma specific viscosity, hematocrit and plasma fibrinogen were lower than those before treatment Group (P <0.05). Conclusion: Danhong injection combined with conventional western medicine has good clinical curative effect on type 2 diabetic nephropathy. It not only can delay or reverse the development of kidney damage, but also can play a protective role on the kidney with definite effect