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目的探讨间质化疗植入剂中人氟安在乳腺癌手术中的应用。方法对212例乳腺癌患者应用中人氟安植入剂作为间质化疗,其中保乳患者174例,改良根治术患者38例。结果随访3至95个月,保乳手术后局部复发2例,局部复发率为1.1%(2/174);乳腺癌根治术后局部复发1例,局部复发率为2.6%(1/38)。6例(2.8%)患者出现植入区域皮肤红肿,多在7～10d内红肿消退;伤口感染、药物颗粒溢出1例(0.5%),经换药清理后二期缝合,伤口愈合。结论中人氟安植入剂作为间质化疗用以处理可能残存的肿瘤细胞,对预防复发具有一定作用。临床应用中,应注意该药物的剂量和植入方法。
Objective To investigate the application of human fluvivamine in breast cancer surgery in interstitial chemotherapy. Methods A total of 212 breast cancer patients were treated with human Fluoroaniline as an interstitial chemotherapy, including 174 breast-conserving patients and 38 modified radical mastectomy. Results The local recurrence rate was 1.1% (2/174) after breast-conserving surgery in 3 to 95 months. Local recurrence rate was 2.6% (1/38) in breast cancer patients after radical operation, . In 6 cases (2.8%), the skin in the implanted area appeared red and swollen, and the redness subsided more in 7 ~ 10 days. One case (0.5%) was infected by the wound and the drug pellet overflowed. Conclusion Flunaride as an interstitial chemotherapy for the treatment of possible residual tumor cells, to prevent recurrence has a role. In clinical application, attention should be paid to the dosage and implantation method of the drug.