利用Novozyme-435酶催化2,2-双(羟甲基)丙酸苄基酯与癸二酸的缩聚反应,再在同一体系中加入己内酯进行酶催化开环反应。反应监测结果表明了,利用酶催化,两种不同的聚合反应在同一反应容器中成功进行并生成了嵌段聚合物。利用动态光散射仪测定了此嵌段聚合物在水溶液中的自组装形成胶束的行为,并利用原子力显微镜观察了固定化后的胶束的形貌。 Polycondensation of 2,2-bis (hydroxymethyl) propionate with sebacic acid was catalyzed by Novozyme-435 enzyme, and caprolactone was added to the same system to perform enzymatic ring-opening reaction. The results of the reaction monitoring showed that with enzyme catalysis two different polymerizations were successfully carried out in the same reaction vessel and block polymers were formed. The self-assembled micelles of the block polymer in aqueous solution were measured by dynamic light scattering (DLS), and the morphology of the micelles was observed by atomic force microscopy.