Objective: To investigate the clinical study of Qiming granule combined with compound anisodine injection in the treatment of diabetic retinopathy. Methods: 104 patients with non-proliferative diabetic retinopathy admitted to department of ophthalmology in Xishui Hospital Affiliated to Hubei University of science and technology from September 2016 to May 2018 were selected as the study subjects. According to the principle of treatment, they were divided into 52 cases in the control group and 52 cases in the treatment group, the clinical efficacy, blood sugar and lipid levels, hemorheological changes and adverse reactions were compared between the two groups. Results: The total effective rate difference between the treatment group (92.31％) and the control group (71.15％) was statistically significant (χ2=7.792, P=0.005). After treatment, the two groups of fasting plasma glucose(FPG), hemoglobin A1c(HbA1c), total cholesterol(TC), low density lipoprotein-cholesterol(LDL-C), whole blood high-viscosity, whole blood cut viscosity, whole blood low-cut viscosity, plasma viscosity, number of microangioma and area of the hemorrhage were significantly lower than before treatment (P<0.05), and the levels of FPG, HbA1c, TC, LDL-C, whole blood high-viscosity, whole blood cut viscosity, whole blood low-cut viscosity, plasma viscosity, number of microangioma and area of the hemorrhage in the treatment group were significantly lower than those in the control group (χ2=0.122, P=0.727). Conclusions: Qiming granule combined with compound anisodine injection can effectively improve the clinical efficacy of patients with non-proliferative DR, and its mechanism may be related to improve blood sugar and blood lipid levels and correct blood rheology disorder, reduce microangioma and hemorrhage. It has clinical promotion significance.