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目的:观察甲氨喋呤(MTX)联合米非司酮对未破裂型异位妊娠的疗效。方法:将符合保守治疗条件的异位妊娠患者137例随机分成两组,治疗组:MTX(50 mg/m2)单次肌内注射,第2天口服米非司酮200 mg,连服3天;对照组:单用MTX(50 mg/m2)肌内注射,两组均同时服用传统中药异位妊娠方加味。定期监测血β-HCG水平及阴道B超监测包块情况,直至正常。结果:治愈率:治疗组91.3%,对照组85.3%,两组间无明显差异(P>0.05),但血β-HCG降至正常时间缩短,住院日减少(P<0.05)。结论:MTX联合米非司酮治疗异位妊娠疗效好,副作用小,可作为临床首选治疗方案。
Objective: To observe the effect of methotrexate (MTX) combined with mifepristone on unruptured ectopic pregnancy. Methods: One hundred and fourty-seven patients with ectopic pregnancy were randomly divided into treatment group (MTX: 50 mg / m2), single intramuscular injection of mifepristone (200 mg) for 3 days ; Control group: MTX alone (50 mg / m2) intramuscular injection, both groups also take traditional Chinese medicine ectopic pregnancy prescription. Regular monitoring of blood β-HCG levels and vaginal B-monitoring mass until normal. Results: The cure rate was 91.3% in the treatment group and 85.3% in the control group. There was no significant difference between the two groups (P> 0.05). However, the reduction of β-HCG to normal time and hospital stay decreased (P <0.05). Conclusion: MTX combined with mifepristone treatment of ectopic pregnancy good curative effect, side effects, can be used as the clinical preferred treatment.