论文部分内容阅读
目的探讨急性脑出血患者血清铁蛋白水平的动态变化及其临床意义。方法观察急性脑出血患者(A组,40例)血清铁蛋白水平的动态变化,并与健康体检者(B组,40例)比较,分析铁蛋白水平与脑出血周围水肿和美国国立卫生院神经功能缺损评分(NIHSS)、GOS评分的相关性。结果 A组发病后20d内血清铁蛋白水平高于B组(P<0.05),第7天达到最高水平[(301.71±186.19)ng/ml vs.(188.46±104.52)ng/ml](P<0.05)。脑出血第3天,患者血清铁蛋白水平与出血病灶周围水肿程度呈正相关(r_s=0.683,P<0.01)。脑出血第3~7天,血清铁蛋白水平与NIHSS和GOS评分呈负相关(r_s=-0.668和r_s=-0.746,P<0.01),预后良好组(11例)患者的血清铁蛋白浓度低于预后不良组(29例)[(264.11±143.67)ng/ml vs.(323.70±171.84)ng/ml](P<0.05)。结论血清铁蛋白参与了脑出血后的病理生理过程,并且和患者预后密切相关。
Objective To investigate the dynamic changes of serum ferritin level in patients with acute cerebral hemorrhage and its clinical significance. Methods The levels of serum ferritin in acute cerebral hemorrhage (A group, 40 cases) were observed and compared with healthy subjects (B group, 40 cases). The levels of ferritin and edema around the cerebral hemorrhage were analyzed. Functional impairment score (NIHSS), GOS score correlation. Results The level of serum ferritin was significantly higher in group A than in group B (P <0.05) within 20 days after onset, reaching the highest level on the seventh day [(301.71 ± 186.19) ng / ml vs. (188.46 ± 104.52) ng / ml] 0.05). On the third day after intracerebral hemorrhage, the level of serum ferritin was positively correlated with the degree of edema around hemorrhage (r_s = 0.683, P <0.01). Serum ferritin levels were negatively correlated with NIHSS and GOS scores (r_s = -0.668 and r_s = -0.746, P <0.01) on days 3 to 7 of cerebral hemorrhage and low serum ferritin levels in patients with good prognosis (n = 11) In the poor prognosis group (29 cases) [(264.11 ± 143.67) ng / ml vs. (323.70 ± 171.84) ng / ml] (P <0.05). Conclusion Serum ferritin is involved in the pathophysiological process after intracerebral hemorrhage and is closely related to the prognosis of patients.