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目的观察钾离子在腹部开放伤合并海水浸泡时对兔心率、心律、血压、血钾及生存期的影响。方法将动物随机分为腹部开放伤+海水持续灌流组(N组,10只)和腹部开放伤+低钾海水持续灌流组(L组,10只),应用腹部开放伤合并海水灌流的动物模型,观察含不同浓度钾海水对动物心率、心律、血压、血钾及生存期的影响。结果①低钾海水灌注组生存时间明显长于普通海水组(P<0.05);②海水持续灌流组血钾浓度明显升高(P<0.05);③海水持续灌流组血压明显降低,心率略有减慢,没有发现有意义的心律失常。结论钾离子在腹部开放性损伤合并海水灌流中对动物的心率、血压和生存期有明显影响,可能与其心肌抑制作用有关;未出现严重心律失常,发生机制不明。
Objective To observe the effect of potassium on heart rate, heart rate, blood pressure, serum potassium and survival time of rabbits with open abdominal wound and seawater immersion. Methods Animals were randomly divided into two groups: open abdominal wound + continuous seawater infusion group (n = 10), open abdominal wound + low potassium seawater continuous infusion group (group L, n = 10) The effects of different concentrations of potassium seawater on heart rate, heart rate, blood pressure, serum potassium and survival rate were observed. Results ① The survival time in hypokalemia saline group was significantly longer than that in normal seawater group (P <0.05); ② The serum potassium concentration in continuous water-fed group was significantly increased (P <0.05); ③ The blood pressure was decreased Slow, no meaningful arrhythmia was found. Conclusions Potassium ion has significant effect on heart rate, blood pressure and survival in open abdominal injury combined with seawater perfusion. It may be related to its myocardial inhibition; no serious arrhythmia occurs, and the mechanism is unknown.