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以焦脱镁叶绿酸-a甲酯为起始原料,通过化学修饰在五元外接环上构筑活性反应区域,经分子内的酯交换、Michael加成和Claisen缩合等经典化学反应,使得132-与17-位通过不同的碳链相互连接,在C-D环端向上形成了双环和螺环结构.同时,利用17-位尾端酯基的化学活性进行胺解和酰化反应,在二氢卟吩色基的最远端建立了不同的化学结构,完成了9个未见报道的具有新颖碳架结构的叶绿素类二氢卟吩衍生物的合成,其化学结构均经UV、IR、1H NMR及元素分析予以证实.
To pyropheophorbide-a methyl ester as a starting material, through chemical modification in the five yuan external loop to build an active reaction area, the intramolecular transesterification, Michael addition and Claisen condensation and other chemical reactions so that the classic 132 - and 17-position through the different carbon chains connected to each other in the CD ring formed on the end of the ring and spiro structure upward at the same time, the use of 17-terminal end of the ester group chemical activity amidation and acylation reaction in dihydrogen In the farthest end of the porphin, different chemical structures were established, and nine new chlorophyllin-containing chlorin derivatives with novel carbon-cage structure were successfully synthesized. The chemical structures of these chlorophylls were confirmed by UV, IR, 1H NMR and elemental analysis to be confirmed.