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采用环磷酰胺、阿霉素、长春新碱及强的松（CHOP）方案，对52例老年人（≥60岁）非何杰金淋巴瘤的治疗进行了分析。将病人分两组，A组：CHOP方案常规药物剂量组；B组：CHOP方案根据病人年龄及体质状态将药物剂量减至A组的1／2～2／3。结果显示B组与A组完全缓解率基本相同，但3年存活率B组（41．0％）高于A组（20．0％）。化疗相关死亡B组（9．1％）低于A组（26.0％），化疗副作用亦明显低于A组。这提示对老年人非何杰金淋巴瘤适当减低比疗药物剂量有利于提高疗效，保证生活质量，延长生存期。
Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimens were used to analyze the treatment of non-Hodgkin’s lymphoma in 52 elderly (≥60 years old) patients. The patients were divided into two groups, group A: CHOP regimen conventional drug dose group; group B: CHOP regimen reduced the dose of the drug to 1/2 to 2/3 of the group A according to the patient’s age and physical status. The results showed that the complete remission rate was basically the same in group B and group A, but the 3-year survival rate in group B (41.0%) was higher than in group A (20.0%). Chemotherapy-related death in group B (9.1%) was lower than in group A (26.0%), and the side effects of chemotherapy were also significantly lower than in group A. This suggests that the appropriate reduction of drug dose for non-Hodgkin’s lymphoma in the elderly is beneficial to improve the efficacy, ensure the quality of life, and prolong the survival period.