INTRODUCTIONrnOsteosarcoma is the most common type of primary bone sarcoma that mostly occurs in teenagers and young adults.1 Osteosarcoma usually grows in the fast?growing bone tissues but often metastasizes into other organs such as lung. It’s a highly aggressive tumor that causes intense pain, decreased range of motion, swelling, and fragile bones in patients. The overall 5 year survival rate for the non?metastatic disease is about 60％–70％, while the survival rate dramatically decreases in patients with metastases and recurrent diseases.2–3 The causes of osteosarcoma are heterogeneous and still not fully understood, therefore a better understanding of the molecular mechanisms underlying osteosarcoma oncogenesis and identification of novel therapeutic targets are urgently needed for the effective treatment of osteosarcoma.