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目的 为寻找新的特异性和敏感性的指标 ,以探讨风湿热的活动性 ,从而提高风湿热和风心病的诊疗水平。方法 用A组乙型溶血链球菌特异性菌膜抗原和 1%植物血凝素 (PHA)作为刺激物 ,分别测定 38例健康对照组 ,30例风湿性心脏病风湿活动组 ,2 4例风湿性心脏病静止组的外周血淋巴细胞贴壁抑制百分率 (Lymphocyteadherencein hibitionpercent,LAIP)和促凝血活性 (Procoagulantactivity ,PCA)。结果 风心病活动组IAIP(34 47%± 4 5 6 % )显著高于风心静止组 (13 5 6 %± 3 31% )和健康对照组 (12 5 0 %±3 73% ) ,而后二者无统计学显著差异。风心活动组、风心静止组、健康对照组的淋巴细胞贴壁抑制指数同PCA相关系数分别为 0 85 94、0 8431、0 82 87,存在着正相关性 ,在统计学上无差异。PCA阳性率略高于LAIP ,但是二者无统计学差异。结论 LAIP在判断风湿活动方面有较大价值。
The purpose is to find new indicators of specificity and sensitivity to explore the activity of rheumatic fever, thereby enhancing the diagnosis and treatment of rheumatic fever and rheumatic heart disease. Methods A group B hemolytic streptococcus specific membrane antigens and 1% phytohemagglutinin (PHA) as stimuli were measured 38 healthy controls, 30 rheumatic heart disease rheumatoid activity group, 24 cases of rheumatoid Lymphocystherencein hibition percentage (LAIP) and procoagulantactivity (PCA) in patients with quiescent heart disease. Results The IAIP (34 47% ± 45 6%) in rheumatic heart activity group was significantly higher than that in resting group (135.6% ± 31.3%) and healthy control group (125.0% ± 3.73%), There was no statistically significant difference. There was a positive correlation between the inhibition index of lymphocyte adhesion and the PCA correlation coefficient of the wind-heart activity group, the wind-centered still group, and the healthy control group, with no statistical difference. The positive rate of PCA was slightly higher than that of LAIP, but there was no significant difference between them. Conclusions LAIP has great value in judging rheumatic activity.