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氟康唑是治疗阴道念珠菌病的推荐药物.早期研究提示氟康唑能延长磺酰脲类口服降糖药的半衰期.虽然没有对照的血糖改变的纪录,也曾有报道同时应用氯磺丙脲(chlorpropamide)、格列本脲(glibenclamide)或格列吡嗪(glipizide)时可伴有低血糖症.这些观察结果提示.同时应用氟康唑和一种口服降糖药时应注意监测血糖浓度,为此,作者研究了29例患阴道炎的绝经后糖尿病妇女(年龄49～88岁,平均64岁)使用氟康唑的安全性.14例随机给予氟康唑,每日50mg14天,15例患者阴道内给予克霉唑(clotrimazole)100mg作同期对照.这些妇女都同时正服用格列齐特(gliclazide17例)或格列本脲(12例).糖尿病的控制通过在研究开始、二周的相互作用期后和抗霉菌治疗停止后四周测定血清果糖胺(fructosamine)和糖化血红蛋白来评价,并在每次就诊时询问她们有关低血糖症状.结果,氟康唑与克霉唑在控制阴道炎症状方面疗效相似,但氟康
Fluconazole is the recommended drug for the treatment of vaginal candidiasis.Early studies have shown that fluconazole can extend the half-life of sulfonylureas oral hypoglycemic agents.Although there is no record of the control of blood glucose changes, it has also been reported at the same time the application of chlorhexidine Chlorpropamide, glibenclamide or glipizide may be associated with hypoglycemia, and these observations suggest that monitoring of blood glucose should be accompanied by the simultaneous use of fluconazole and an oral hypoglycemic agent To this end, the authors studied the safety of fluconazole use in 29 postmenopausal women with diabetes mellitus (aged 49-88 years, mean age 64), and 14 were randomized to fluconazole 50 mg daily for 14 days, Fifteen patients received 100 mg of clotrimazole intravaginally as a control during the same period, and all of the women were taking gliclazide (17) or glibenclamide (12) at the same time. Diabetes was controlled at the beginning of the study, Serum fructosamine and glycosylated hemoglobin were measured after weeks of interaction and four weeks after antifungal treatment was stopped, and were asked about their hypoglycemic symptoms at each visit. As a result, fluconazole and clotrimazole were under control Vaginal inflammation Similar terms of efficacy, but fluconazole