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近年动物试验证明心肌缺血预适应有一种保护作用。本组分析了近3年我院急性前壁心肌梗塞110例病人缺血预适应对心肌梗塞的影响。其中男77例,女33例。心肌梗塞前有预缺血者69例(A组),无预缺血者41例(B组)。资料分析显示:B组心肌梗塞时心肌坏死范围、心肌酶峰值、心功能损害、室壁瘤形成及死亡率均高于A组,两组差异有显著性。还就心肌缺血预适应发生时间及其对心肌保护作用之间的关系,缺血预适应的可能机制及临床意义进行了讨论。
In recent years, animal experiments show that myocardial ischemic preconditioning has a protective effect. This group analyzes the past 3 years in our hospital acute anterior myocardial infarction in 110 patients with ischemic preconditioning on myocardial infarction. There were 77 males and 33 females. There were 69 patients with pre-ischemic pre-infarction (group A) and 41 patients without pre-ischemic (group B). Data analysis showed that: the range of myocardial necrosis, peak of myocardial enzymes, cardiac dysfunction, aneurysm formation and mortality in group B were higher than those in group A, the difference was significant. The timing of myocardial ischemic preconditioning and its role in cardioprotection was also discussed, and the possible mechanisms and clinical implications of ischemic preconditioning were discussed.