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目的观察益生菌制剂美常安对肝硬化亚临床肝性脑病患者的血氨水平、内毒素以及数字连接试验的影响。方法肝硬化亚临床肝性脑病40例,随机分为对照组及治疗组(各20例),分别给予常规治疗、常规治疗加美常安口服,疗程4周。采用血氨测定仪、鲎试剂法及数字连接试验分别测定2组患者血氨、血浆内毒素水平及数字连接所需时间。结果治疗组患者治疗前后:血氨水平分别为(2.16±1.81)、(1.37±1.20)ng/L(P<0.05);血浆内毒素水平分别为(0.32±0.17)、(0.14±0.03)EU/ml(P<0.01);数字连接试验所需时间分别为(98±31)、(56±32)s(P<0.01)。对照组治疗前后3项指标差异均无统计学意义(P>0.05)。结论益生菌制剂(美常安)可有效防治肝硬化患者肝性脑病及内毒素血症。
Objective To observe the effect of probucol propionate on serum ammonia level, endotoxin and digital connectivity in cirrhotic patients with subclinical hepatic encephalopathy. Methods Forty cirrhotic subclinical hepatic encephalopathy cases were randomly divided into control group and treatment group (n = 20 each). The patients were given routine therapy and routine treatment was given orally for 4 weeks. Using blood ammonia analyzer, 鲎 reagent method and digital connection test were measured in two groups of patients with blood ammonia, plasma endotoxin levels and digital connection time required. Results Before and after treatment, the levels of serum ammonia were (2.16 ± 1.81) and (1.37 ± 1.20) ng / L, respectively (P <0.05). The levels of plasma endotoxin were (0.32 ± 0.17) and / ml (P <0.01). The time required for digital connection test was (98 ± 31) and (56 ± 32) s, respectively (P <0.01). There was no significant difference in the three indexes in the control group before and after treatment (P> 0.05). Conclusion Probiotics (Mei Chang An) can effectively prevent and treat hepatic encephalopathy and endotoxemia in cirrhotic patients.