肝脂肪酶是由肝实质细胞合成的一种具有磷脂肪酶A1和甘油三酯水解酶活性 ,对血浆脂质转运有重要作用的胞外蛋白 ,主要参与高密度脂蛋白的重构和乳糜微粒残骸、低密度脂蛋白的代谢以及胆固醇的逆向转运。肝脂肪酶活力异常与动脉粥样硬化及糖尿病有较高的相关性。肝脂肪酶活力受激素及载脂蛋白的影响 ,肝脂肪酶基因启动子的多态性及肝脂肪酶基因错义也影响酶的活力。 Liver lipase is synthesized by the liver parenchyma cell with phospholipase A1 and triglyceride hydrolase activity, lipid transport of plasma lipids play an important role in extracellular proteins, mainly involved in the reconstruction of high density lipoprotein and chylomicrons Wreckage, metabolism of LDL, and the reverse transport of cholesterol. Hepatic lipase activity abnormalities and atherosclerosis and diabetes have a higher correlation. Hepatic lipase activity is affected by hormones and apolipoproteins, and polymorphisms in the hepatic lipase gene promoter and hepatic lipase gene missense also affect enzyme activity.