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由性腺和肾上腺产生的甾体激素分为五大类,即雌激素、孕激素、雄激素、糖皮质激素和盐皮质激素。性腺甾体激素控制生殖系统的分化、发育及生长,引起和维持副性征,调节生殖功能等。每一种甾体激素的作用都是通过特异性受体。深入了解受体的真面目,有助于理解其激素作用的机理,认识受体有关病变的临床病理过程,指导理论研究和临床实践。近年来,随着生物化学技术和基因工程技术的不断发展,借助于单克隆抗体、亲和标记、以及基因克隆等技术,对甾体激素受体的研究取得了突破性进展。本文简述雌激素与孕激素受体。
Steroid hormones produced by the gonads and adrenals fall into five broad categories: estrogen, progestin, androgens, glucocorticoids and mineralocorticoids. Gonadal steroid hormones control the differentiation, development and growth of the reproductive system, cause and maintain the secondary sex characteristics, regulate reproductive function. The role of each steroid hormone is through a specific receptor. Understanding the true nature of the receptor in depth helps to understand the mechanism of its hormonal effects and to understand the clinical and pathological processes underlying the receptor, guiding theoretical research and clinical practice. In recent years, with the continuous development of biochemical technology and genetic engineering technology, breakthroughs have been made in the research of steroid hormone receptors by means of monoclonal antibodies, affinity tags and gene cloning techniques. This article describes estrogen and progesterone receptors.