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目的:比较氟伐他汀钠胶囊和氟伐他汀钠缓释片的疗效。方法:将60例高脂血症患者随机分为两组,胶囊组30例,予氟伐他汀钠胶囊40mg,2次/d;缓释片组30例,予氟伐他汀钠缓释片80mg/d,4周为一疗程。治疗前及3个月后检测血清总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、甘油三酯(TG),监测肝功能,观察不良反应。结果:两组治疗前后血脂测定值比较,差异有统计学意义(P<0.05);胶囊组总有效率为93.33%,缓释片组为96.67%,两组总有效率比较差异无统计学意义(P>0.05)。胶囊组不良反应相对较多。结论:氟伐他汀钠胶囊和氟伐他汀钠缓释片的降脂疗效均比较显著,氟伐他汀钠缓释片的安全性优于氟伐他汀钠胶囊。
Objective: To compare the efficacy of fluvastatin sodium capsules and fluvastatin sodium sustained-release tablets. Methods: Sixty patients with hyperlipidemia were randomly divided into two groups: capsule group (30 cases), fluvastatin sodium capsule (40 mg twice daily), sustained-release tablets group (n = 30), fluvastatin sodium sustained-release tablets / d, 4 weeks for a course of treatment. Serum total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) and triglyceride (TG) were measured before and three months after treatment. Liver function was monitored and adverse reactions were observed. Results: Before and after treatment, the measured values of blood lipids in the two groups were significantly different (P <0.05). The total effective rate was 93.33% in the capsule group and 96.67% in the sustained-release tablets group. There was no significant difference in the total effective rate between the two groups (P> 0.05). Capsule group had relatively more adverse reactions. Conclusion: The efficacy of fluvastatin sodium capsules and fluvastatin sodium sustained-release tablets are significant. The safety of fluvastatin sodium sustained-release tablets is better than that of fluvastatin sodium capsules.