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目的探讨水通道蛋白1、3(AQP1、AQP3)在上皮性卵巢癌中的表达及其意义。方法采用免疫组织化学方法检测上皮性卵巢良性、交界性、恶性肿瘤中肿瘤及腹膜组织中AQP1和AQP3的表达,同时检测血管内皮生长因子(VEGF)表达并以CD105标记各组织微血管内皮细胞测定微血管密度(MVD)。结果卵巢癌患者腹膜中AQP1、AQP3表达明显高于良性肿瘤者(P<0.05)。与卵巢肿瘤性质有关;卵巢癌患者中,有腹水(尤其是腹水量≥1000ml)和淋巴结转移者AQP1、AQP3的表达明显高于无腹水者(P<0.05)。AQP3的表达与卵巢癌病理分期分级有关。结论 AQP1、AQP3参与卵巢癌发生发展、侵袭转移和腹水形成。腹膜组织上AQP1、AQP3的高表达与肿瘤盆腔扩散和腹水生成有密切关系。
Objective To investigate the expression and significance of AQP1 and AQP3 in epithelial ovarian cancer. Methods The expression of AQP1 and AQP3 in tumor and peritoneum of benign, borderline and malignant epithelial ovarian tumors was detected by immunohistochemical method. The expression of vascular endothelial growth factor (VEGF) and the expression of vascular endothelial growth factor (VEGF) were detected with microvessel endothelial cells Density (MVD). Results The expression of AQP1 and AQP3 in peritoneum of patients with ovarian cancer was significantly higher than that of benign tumor (P <0.05). And the nature of ovarian cancer; ovarian cancer patients, ascites (especially ascites ≥ 1000ml) and lymph node metastasis AQP1, AQP3 expression was significantly higher than those without ascites (P <0.05). AQP3 expression and ovarian cancer staging related. Conclusion AQP1 and AQP3 are involved in the development, invasion and metastasis of ovarian cancer and the formation of ascites. Peritoneal tissue AQP1, AQP3 high expression and tumor pelvic spread and ascites are closely related.