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目的探讨高原地区炎症性肠病发病率高的原因。方法应用电子结肠镜对患者进行全结肠镜检查,全部达回盲部,在退镜时,在炎症最明显处取活检4块,以10%甲醛液固定,送病理室检验。结果高原地区炎症性肠病124例,其中镜下黏膜充血水肿114例(91.9%),血管网模糊98例(79.0%),浅表溃疡76例(61.3%),纵性溃疡46例(37.1%),肠腔狭窄31例(25.0%),阿弗他溃疡28例(22.6%),炎性息肉23例(18.5%),肠壁僵硬19例(15.3%)。结论高原地区缺氧、特殊地理环境及生活习惯可能损伤肠黏膜屏障功能,是发病率高的原因。
Objective To explore the causes of high incidence of inflammatory bowel disease in the plateau area. Methods All patients underwent colonoscopy with electronic colonoscopy, all of them reached the blind area. When the mirror was removed, 4 biopsies were taken at the most obvious inflammation and fixed in 10% formalin. The pathological examination was performed. Results There were 124 inflammatory bowel diseases in the plateau area, including mucosal congestion and edema in 114 cases (91.9%), vascular network obstruction in 98 cases (79.0%), superficial ulcer in 76 cases (61.3%) and longitudinal ulcer in 46 cases (37.1 (25.0%), 28 cases of aphthous ulcer (22.6%), inflammatory polyp in 23 cases (18.5%) and intestinal wall stiffness in 19 cases (15.3%). Conclusion The hypoxia in the plateau, special geographical environment and living habits may damage the intestinal mucosal barrier function, which is the reason of high incidence.