目的探讨兰索拉唑对消化性溃疡(PU)的临床疗效及应用价值。方法选取在我院治疗的PU患者168例,随机分为观察组和对照组,两组采用相同的西医常规治疗方案,对照组给予奥美拉唑进行治疗,观察组给予兰索拉唑进行治疗,观察两组的临床疗效及不良反应发生情况。结果观察组治愈45例,显效21例,有效14例,无效4例,总有效率为95.24%;对照组治愈22例,显效30例,有效18例,无效14例,总有效率为83.33%,两组临床疗效比较,差异有统计学意义(P<0.05)。观察组不良反应发生率为5.95%,对照组不良反应发生率为10.71%,观察组不良反应发生率低于对照组,但经统计学分析比较,差异无统计学意义(P>0.05)。两组治疗有效患者随访1年后,观察组复发率为21.25%,对照组复发率为38.57%,两组复发率比较,差异有统计学意义(P<0.05)。结论采用兰索拉唑治疗PU的临床疗效优于奥美拉唑,幽门螺旋杆菌(Hp)根除率高,不良反应轻微,值得在临床上大力推广使用。 Objective To investigate the clinical efficacy and application value of lansoprazole on peptic ulcer (PU). Methods 168 cases of PU patients treated in our hospital were randomly divided into observation group and control group. The two groups were treated with the same conventional western medicine. The control group was treated with omeprazole. The observation group was treated with lansoprazole , To observe the clinical efficacy and adverse reactions in both groups. Results In observation group, 45 cases were cured, 21 cases were markedly effective, 14 cases were effective and 4 cases were ineffective. The total effective rate was 95.24%. In control group, 22 cases were cured, 30 cases were markedly effective, 18 cases were effective and 14 cases were ineffective. The total effective rate was 83.33% The difference between the two groups was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 5.95%, the incidence of adverse reactions in the control group was 10.71%, and the incidence of adverse reactions in the observation group was lower than that in the control group. However, the difference was not statistically significant (P> 0.05). After one year follow-up, the recurrence rate was 21.25% in the observation group and 38.57% in the control group. There was significant difference between the two groups (P <0.05). Conclusion The clinical efficacy of lansoprazole in the treatment of PU is better than that of omeprazole. The eradication rate of H. pylori is high and the adverse reactions are mild. It is worth to be popularized in clinic.