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布氏菌苗治疗慢性布氏菌病(下称布病),早已广泛地应用于临床,但菌苗剂量文献未曾规定。1981年4月,我地区某县卫生防疫站曾用大剂量布氏菌苗治疗布病16例,全程14针,经静脉注射或滴注,菌苗一次最大用量为924亿菌体,最小量为100亿菌体,个别患者全程用量累计达到6,102.5亿菌体,用药后病人反应强烈。体温最高达41.8℃者有9人,一般波动在39.3℃～41.8℃之间。普遍有恶心,呕吐、食欲减退。部分患者自诉腰部疼痛,有7人出现肉眼血尿,2人心音低钝。有15人(无肝病史)的肝脏不同程度受到损害:3人黄疸指数在10个单位以上,8人硫
Brucella vaccine for the treatment of chronic brucellosis (hereinafter referred to as brucellosis), has long been widely used in clinical, but the dose of vaccine literature has not provided for. In 1981 April, a county in our county health and epidemic prevention station has used high-dose brucellosis vaccine treatment of brucellosis in 16 cases, the entire 14-needle, intravenous injection or instillation, the maximum amount of bacilli once the vaccine was 92.4 billion cells, the minimum amount 100 million bacteria, the total amount of individual patients totaled 6,102.5 million bacteria, the patient reacted strongly. The body temperature up to 41.8 ℃, 9 people, the general fluctuations in the 39.3 ℃ ~ 41.8 ℃ between. Common nausea, vomiting, loss of appetite. Some patients complained of lumbar pain, there were seven people with gross hematuria, 2 people heart sound low blunt. There are 15 people (no history of liver disease) liver damage to varying degrees: 3 jaundice index above 10 units, 8 people sulfur