论文部分内容阅读
目的探讨测定尿微量白蛋白、α1-微球蛋白和免疫球蛋白G,对肿瘤患者化疗期间肾功监测的临床意义。方法 130例患者在化疗前1天及化疗第10天检测尿微量白蛋白、α1-微球蛋白和免疫球蛋白G,并检测患者同期的血肌酐及尿素。结果化疗前、后患者尿微量白蛋白、α1-微球蛋白和免疫球蛋白G数值变化明显,差异有统计学意义(P<0.01),而化疗前后血尿素和肌酐数值无明显变化,差异无统计学意义(P>0.05)。结论应用尿微量白蛋白、α1-微球蛋白和免疫球蛋白G作为肿瘤化疗患者肾功监测指标,较常规指标血尿素氮、肌酐更灵敏,可早期有效地反映化疗所致患者肾功能损害。
Objective To investigate the clinical significance of urine microalbumin, α1-microglobulin and immunoglobulin G in the monitoring of renal function of tumor patients during chemotherapy. Methods One hundred and thirty patients were tested for urinary albumin, α1-microglobulin and immunoglobulin G on the 1st day before chemotherapy and on the 10th day after chemotherapy. Serum creatinine and urea in the same period were measured. Results The values of urinary albumin, α1-microglobulin and immunoglobulin G in patients before and after chemotherapy were significantly different (P <0.01), while the values of blood urea and creatinine did not change significantly before and after chemotherapy Statistical significance (P> 0.05). Conclusions Urine microalbumin, α1-microglobulin and immunoglobulin G are the indicators of renal function in patients undergoing chemotherapy. They are more sensitive than conventional indicators of blood urea nitrogen and creatinine, and can early and effectively reflect the renal damage caused by chemotherapy.