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采用对照研究方法，比较必压生（Pitressin）和垂体后叶素控制食管静脉曲张破裂出血（EVB）的临床疗效。必压生6小时和12小时完全止血率分别为45．4％（10／22）和72．7％（16／20），垂体后叶素则为20％（4／20）和40％（8／20）（P＜0．05）；前者起效时间为4．47小时，达到完全止血时为8．7小时；后者分别为8．8小时和22．2小时（P＜0．05）；24小时和36小时的输血量必压生组明显少于对照组（P＜0．05）。结果表明，必压生能迅速有效地控制EVB，止血效果优于垂体后叶素，但两者在病死率、再出血方面无显著性差异。
A controlled study was conducted to compare the clinical efficacy of pitressin and vasopressin in the management of esophageal variceal bleeding (EVB). The complete hemostatic rates at 6 and 12 hours after PPH were 45.4% (10/22) and 72.7% (16/20), respectively, whereas pituitrin was 20% (4/20) and 40% 8/20) (P <0.05). The former onset time was 4.47 hours and reached 8.7 hours after complete hemostasis. The latter was 8.8 hours and 22.2 hours respectively (P <0.05). 05). Blood transfusion volumes at 24 hours and 36 hours were significantly lower in the stress group than in the control group (P <0.05). The results showed that the pressure will be able to quickly and effectively control the EVB, hemostatic effect is better than pituitrin, but the two in terms of mortality, rebleeding no significant difference.