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目的:考察镇痛泵中酒石酸布托啡诺、盐酸曲马多及氟哌利多注射剂在0.9%氯化钠注射液中配伍的稳定性。方法:在(25±1)℃条件下,考察酒石酸布托啡诺、盐酸曲马多及氟哌利多注射剂在0.9%氯化钠注射液中配伍后72 h内不同时间点的外观、p H变化,并用高效液相色谱法测定配伍液中各主药的含量。结果:在72 h内配伍液无色澄清,p H值稳定,酒石酸布托啡诺、盐酸曲马多及氟哌利多药物含量未见明显变化。结论:在(25±1)℃条件下,酒石酸布托啡诺、盐酸曲马多及氟哌利多注射剂在0.9%氯化钠注射液中配伍后72 h内保持稳定。
OBJECTIVE: To investigate the stability of compatibility of butorphanol tartrate, tramadol hydrochloride and droperidol injection in 0.9% sodium chloride injection in analgesia pump. Methods: The appearances of butorphanol tartrate, tramadol hydrochloride and droperidol injection at different time points within 72 hours after compatibility with 0.9% sodium chloride injection were investigated under the conditions of (25 ± 1) ℃. P H Changes, and high performance liquid chromatography to determine the compatibility of the main drug content. Results: During 72 h, the compatibility of the solution was clear and colorless, and the pH value was stable. The contents of butorphanol tartrate, tramadol hydrochloride and droperidol did not change significantly. CONCLUSION: Butorphanol tartrate, tramadol hydrochloride and droperidol injection remain stable within 72 h after compatibility with 0.9% sodium chloride injection at (25 ± 1) ℃.