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本文报告应用高效液相色谱技术测定9例消化性溃疡.8例肝硬化和8例慢性肾功能不全病人口服150mg雷尼替丁(ranitidine)后的消除半衰期。溃疡病人为1.98小时,肝硬化病人为2.55小时,而慢性肾功能不全病人为4.93小时。结果表明肾功能不全病人中雷尼替丁消除明显降低。在肾功能严重受损时(内生肌酐清除率小于30ml/min),建议常规150mg剂量减半使用。
This article reports the use of high performance liquid chromatography for the determination of peptic ulcer in nine patients. Eight patients with cirrhosis and eight chronic renal failure patients were treated with 150 mg of ranitidine orally for half-life elimination. 1.98 hours for ulcer patients, 2.55 hours for patients with cirrhosis, and 4.93 hours for patients with chronic renal insufficiency. The results show that patients with renal insufficiency in the elimination of ranitidine significantly reduced. Severe renal function (endogenous creatinine clearance rate of less than 30ml / min), it is recommended to halve the use of conventional 150mg dose.