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目的:观察奥美拉唑、阿莫西林、甲硝唑三者联合治疗Hp感染胃溃疡的临床疗效。方法:选取本院2015年1月-2016年11月收治的Hp感染胃溃疡患者80例,随机分为观察组及对照组,各40例。所有患者均给予奥美拉唑,观察组加入阿莫西林及甲硝唑。观察两组血清炎症因子、胃泌素水平变化情况及临床疗效。结果:治疗后观察组血清炎症因子各相关指标及胃泌素指标水平均优于对照组,差异具有统计学意义(P<0.05);观察组临床总有效率(95%)高于对照组(75%),差异具有统计学意义(P<0.05)。结论:奥美拉唑、阿莫西林、甲硝唑三者联合治疗Hp感染胃溃疡,患者血清炎症因子水平下降明显,胃泌素各相关指标有效改善,临床疗效显著,值得推广。
Objective: To observe the clinical efficacy of combination of omeprazole, amoxicillin and metronidazole in the treatment of Hp-infected gastric ulcer. Methods: Eighty patients with Hp-infected gastric ulcer admitted from January 2015 to November 2016 in our hospital were randomly divided into observation group and control group, 40 cases each. All patients were given omeprazole, the observation group added amoxicillin and metronidazole. Serum inflammatory factors and gastrin levels and clinical efficacy were observed. Results: After treatment, serum inflammatory cytokines and gastrin indexes in observation group were better than those in control group (P <0.05). The total effective rate (95%) in observation group was higher than that in control group 75%), the difference was statistically significant (P <0.05). Conclusion: Combination of omeprazole, amoxicillin and metronidazole in the treatment of gastric ulcer caused by Hp can significantly reduce the levels of serum inflammatory cytokines and improve the relevant indexes of gastrin. The clinical efficacy is significant and worthy of promotion.