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目的比较低血糖指数(GI)高膳食纤维(DF)膳食和高GI低DF膳食+阿卡波糖对初诊2型糖尿病(T2DM)患者血糖、血脂谱的影响。方法采用随机交叉设计,19例初诊T2DM患者随机分组,先后接受低GI高DF膳食或高GI低DF膳食+阿卡波糖治疗,治疗期5d,洗脱期3d。结果低GI高DF膳食后和高GI低DF膳食+阿卡波糖治疗后FPG分别自(7.64±1.58)mmol/L和(7.64±1.58)mmol/L降至(6.56±1.64)mmol/L和(6.39±1.23)mmol/L(P<0.05或P<0.01),PPG峰值分别自(15.82±2.06)mmol/L和(15.82±2.06)mmol/L降至(11.86±2.87)mmol/L和(10.34±2.36)mmol/L(P<0.05或P<0.01),血糖曲线下面积(AUCg)分别自(27.69±3.98)mmol/L·h和(27.69±3.98)mmol/L·h降至(19.82±3.44)mmol/L·h和(17.72±3.35)mmol/L·h(P均<0.01),但治疗后两组间比较差异无统计学意义。低GI高DF治疗后,LDL-C自(3.75±0.59)mmol/L降至(3.33±0.70)mmol/L(P<0.05),其他血脂指标也有不同程度的改善,但差异无统计学意义(P>0.05)。结论低GI高DF治疗显著改善LDL-C,并与高GI低DF膳食+阿卡波糖治疗一样,能显著改善初诊T2DM患者的FPG、PPG峰值和AUCg。
Objective To compare the effects of low GI dietary fiber (DF) and high GI low DF diet + acarbose on blood glucose and lipid profile in newly diagnosed type 2 diabetes mellitus (T2DM). Methods Randomized crossover design was used in 19 cases of newly diagnosed T2DM patients. Patients with low GI, high DF or high DF, low DF diet and acarbose treatment were treated with 5 days of treatment and 3 days of elution. Results FPG decreased from (7.64 ± 1.58) mmol / L and (7.64 ± 1.58) mmol / L to (6.56 ± 1.64) mmol / L after treatment with low GI, high DF and high GI, low DF and acarbose, respectively And (6.39 ± 1.23) mmol / L (P <0.05 or P <0.01) respectively. The PPG peak value decreased from (15.82 ± 2.06) mmol / L and (15.82 ± 2.06) mmol / L to (11.86 ± 2.87) mmol / L And (10.34 ± 2.36) mmol / L (P <0.05 or P <0.01). The area under the curve of blood glucose (AUCg) was (27.69 ± 3.98) mmol / L · h and (27.69 ± 3.98) mmol / L · h (19.82 ± 3.44) mmol / L · h and (17.72 ± 3.35) mmol / L · h, respectively (all P <0.01). However, there was no significant difference between the two groups after treatment. LDL-C decreased from (3.75 ± 0.59) mmol / L to (3.33 ± 0.70) mmol / L (P <0.05) after low GI and high DF treatment, while other lipid parameters also improved to some extent, but the difference was not statistically significant (P> 0.05). Conclusions Low GI, high DF treatment can significantly improve LDL-C, and can significantly improve FPG, PPG peak and AUCg in newly diagnosed T2DM patients as well as high-GI low DF diet plus acarbose treatment.