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目的探讨骨桥蛋白OPN和粘附蛋白CD44v6在肺小细胞癌和肺鳞状细胞癌进展中所起的作用及其对患者预后的影响。方法应用免疫组织化学法检测134例肺癌组织标本中OPN和CD44v6的表达情况,比较分析肺小细胞癌患者和肺鳞状细胞癌患者的3年生存率。结果 OPN和CD44v6在肺小细胞癌中的表达均明显低于在肺鳞状细胞癌中的表达,差异有统计学意义(P<0.01);在肺鳞状细胞癌中,OPN和CD44v6的表达呈正相关(r=0.395,P<0.01);在肺鳞状细胞癌中仅CD44v6的表达差异有统计学意义(P<0.05)。两种肺癌患者3年生存率差异有统计学意义(P<0.05)。结论提示CD44v6可作为判断肺鳞状细胞癌预后的独立指标,而OPN不可作为其预后的独立指标,但二者可以联合作为判断肺鳞状细胞癌预后的参考指标。
Objective To investigate the role of osteopontin OPN and adhesion protein CD44v6 in the progression of small cell lung cancer (SLC) and squamous cell lung carcinoma (SLC) and its effect on the prognosis of patients. Methods The expression of OPN and CD44v6 in 134 specimens of lung cancer was detected by immunohistochemistry. The 3-year survival rates of patients with small cell lung cancer and squamous cell lung cancer were analyzed. Results The expressions of OPN and CD44v6 in small cell lung cancer were significantly lower than those in lung squamous cell carcinoma (P <0.01). The expression of OPN and CD44v6 in lung squamous cell carcinoma (R = 0.395, P <0.01). The expression of CD44v6 in lung squamous cell carcinoma was significantly different (P <0.05). The difference of 3-year survival rates between the two lung cancer patients was statistically significant (P <0.05). Conclusions CD44v6 can be used as an independent index to judge the prognosis of lung squamous cell carcinoma, OPN can not be used as an independent index of prognosis, but both can be used as a reference index to judge the prognosis of lung squamous cell carcinoma.