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采用大鼠单侧肾切除后一次小剂量(3mg/kg)阿霉素尾静脉注射后造成肾小球硬化模型长达8个月的观察。结果表明:阿霉素注射3个月后出现大量蛋白尿和低蛋白血症、高胆固醇血症,无肾小球硬化。注射5个月后所有大鼠发展成为局灶性、节段性肾小球硬化。8个月后肾小球硬化更严重,伴有肾小管间质病变,其硬化率达49.90％。肾小球硬化率与尿蛋白呈正相关(r=0.97 P<0.01),与血清肌酐呈正相关(r=0.87 P<0.05)。认为阿霉素所诱导大鼠慢性进行性肾小球病变导致肾功能不全与人类的局灶性、节段性肾小球硬化病变相似。
A small dose (3 mg / kg) of doxorubicin injected into the tail vein of a rat after unilateral nephrectomy resulted in the observation of glomerulosclerosis model for up to 8 months. The results showed that: 3 months after injection of doxorubicin appeared a large number of proteinuria and hypoproteinemia, hypercholesterolemia, no glomerulosclerosis. After 5 months of injection, all rats developed focal, segmental glomerulosclerosis. Glomerulosclerosis was more serious after 8 months, with tubulointerstitial lesions, the sclerosis rate of 49.90%. The rate of glomerulosclerosis was positively correlated with urinary protein (r = 0.97 P <0.01), and positively correlated with serum creatinine (r = 0.87 P <0.05). That doxorubicin-induced chronic progressive glomerular lesions in rats lead to renal insufficiency and focal human focal segmental glomerulosclerosis lesions similar.