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目的 观察糖皮质激素与长效 β2 受体激动剂吸入及单纯糖皮质激素吸入治疗小儿哮喘的临床疗效差别。方法 广州医学院第二附属医院 2 0 0 2年 3月至 2 0 0 4年 5月儿科急诊及门诊诊断为哮喘的患儿 14 1例 ,按单双日进行随机分组 ,治疗组选用糖皮质激素与长效 β2 受体激动剂 (舒利迭 )吸入 ,对照组行单纯激素吸入 (辅舒酮 )治疗 ,对其临床疗效及肺功能指标进行比较并进行统计学分析。结果 接受舒利迭治疗并成功随访的有 6 3例 ,接受辅舒酮治疗并成功随访的有 6 2例 ,两者临床疗效指标比较差异经非参数检验具有统计学意义。同时PEFR之间比较 ,差异经方差分析同样具统计学意义。结论 对中到重度的哮喘患儿 ,糖皮质激素与长效 β2 受体激动剂吸入较单纯激素吸入治疗能较好地控制并改善哮喘的症状。
Objective To observe the clinical effects of inhaled glucocorticoid and long-acting β2 receptor agonist and simple glucocorticoid inhalation on children with asthma. Methods A total of 141 pediatric patients diagnosed as asthma at the Second Affiliated Hospital of Guangzhou Medical College from March 2002 to May 2004 were randomly divided into groups according to their single and double days. The patients in the treatment group were given glucocorticoids Hormone and long-acting β2 receptor agonist (seretide) inhalation, the control group were treated with simple hormone inhalation (Fu Shu ketone), its clinical efficacy and lung function indicators were compared and statistically analyzed. Results Sixty three patients were followed up with seretide and were followed up successfully. Sixty two patients were followed up with fuflunomide. The difference of clinical curative effect between the two groups was statistically significant by nonparametric test. PEFR at the same time between the differences by the analysis of variance with the same statistical significance. Conclusion In children with moderate to severe asthma, glucocorticoid and long-acting β2 agonist inhalation can better control and improve asthma symptoms than simple hormone inhalation therapy.