21-三体患者和患者双亲各8例以及核型正常者对照30例,以氨银染色法观察近端着丝粒染色体的银染和联合。观察结果示银染及联合的机会,患者及其双亲均显著高于相应年龄及性别的正常对照。此现象提示患者双亲可能受某种因素的影响,使银染的遗传稳定性发生突变,而使银染率和联合率增高,继致染色体不分离危险性增大。这些改变可能与三体异常有关。 21 cases of trisomy and 8 cases of patients and parents of patients with normal karyotype control 30 cases, silver staining of proximal centromere silver staining and combination. The results showed that the chance of silver staining and union, patients and their parents were significantly higher than the corresponding age and gender of the normal control. This phenomenon suggests that parents may be affected by some factors, so that genetic stability of silver stain mutation, and silver staining rate and combined rate increased, following the risk of chromosome separation does not increase. These changes may be related to trisomy.