Craven等曾报告用大剂量Ketoconazole治疗过6例中枢神经系统霉菌感染。其中3例为球孢子菌脑膜炎,用Ketoconazole治疗,每日1200mg,获显著效果。另1例为脑组织胞浆菌病,用Ketoconazole600mg/日治疗,也获得成功。本文报告用较小剂量的Ketoconazole治疗2例中枢神经系统霉菌感染也取得明显的临床改善。病例报告例1,男,66岁,右上肢贾克森氏癫痫,以后经培养和活检确诊为复发的播散性组织胞浆菌病。CT扫描可见在左额矢状窦旁区有一直径为14mm的结节,右额后上部可见两个直径为6mm的结节,其周围伴脑水肿。经一疗程的二性霉素B治疗后癫痫缓解,CT示这三个结节变小,水肿消退。此 Craven et al have reported 6 cases of central nervous system fungal infection with large doses of Ketoconazole. Three of them were coccidioidomycosis meningitis, treated with Ketoconazole, 1200 mg daily, with significant results. Another case of cerebral histoplasmosis, with Ketoconazole600mg / day treatment, but also to be successful. This article reports that a smaller dose of Ketoconazole treatment of 2 cases of central nervous system fungal infection also achieved significant clinical improvements. Case Report Example 1, male, 66 years old, right upper extremity Jarkist’s epilepsy, later confirmed by culture and biopsy as recurrent disseminated histoplasmosis. The CT scan showed that there was a nodule 14 mm in diameter in the region of the left frontal sagittal sinus. Two nodules with a diameter of 6 mm were visible in the upper part of the right forehead. The periphery was accompanied by cerebral edema. After a course of treatment of amphotericin B epilepsy relief, CT showed three nodules smaller, edema subsided. this