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褪黑激素(Melatonin,MT)是松果体内分泌的一种吲哚类激素,具有广泛的生理作用。它不仅与个体发育、生殖功能、脑功能相关,且参与催眠、镇静、镇痛和免疫效应等活动。某些肿瘤和精神神经等系统疾病的发生和发展也与褪黑激素的独特昼夜排泌节律有联系。为了使这种内源性多效应的生理活性调质能尽快地应用于诊断和治疗,简化MT的合成方法并进而合成更多新的MT衍生物,研究它们的构效关系,无疑是一值得注意的课题。
Melatonin (MT) is an indole hormone secreted by pineal gland and has a wide range of physiological functions. It not only with the individual development, reproductive function, brain function related, and involved in hypnosis, sedation, analgesic and immune effects and other activities. Some tumors and nervous system diseases such as the occurrence and development of melatonin with a unique diurnal excretion rhythm linked. In order to make this endogenous multi-effect physiologically active modulating and quenching applicable to diagnosis and treatment as soon as possible, to simplify the synthesis of MT and further to synthesize more new MT derivatives, it is undoubtedly worth to study their structure-activity relationship Attention topics.