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长久以来公认DNA聚合酶不能仅以核苷酸底物从头合成DNA,必须要在一段特定长度的DNA或RNA引物末端开始聚合DNA。而来自华中科技大学、哈佛大学、日本地球海洋科技局的研究人员近期发现了自然界已知的第一个不需要引物的DNA聚合酶,这不仅在聚合酶进化研究中有重要意义,而且还蕴藏了在核酸合成和测序技术中的应用价值。
It has long been recognized that DNA polymerases can not synthesize DNA de novo with nucleotide substrates only, and DNA must be polymerized at the end of a specific length of DNA or RNA primer. Researchers from Huazhong University of Science and Technology, Harvard University and Japan’s Geo-Marine Science and Technology Agency recently discovered the first DNA polymerase that is not known to be known in nature, which is not only significant in the study of polymerase evolution, but also contains The value of nucleic acid synthesis and sequencing technology.