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(1)本组以组织化学方法观察了435例鼻咽癌的DNA、 RNA、PAS阳性物质及网状纤维的改变情况;发现肿瘤细胞中DNA及RNA的含量一般的高于正常粘膜上皮细胞,DNA含量和细胞分化成反比,继发肿瘤多于原发肿瘤,RNA在癌巢边沿癌细胞较中心处者为多。(2)分化较低的癌细胞、瘤巨细胞和分裂中之癌细胞的PA5反应多阴性;分化较高的癌细胞呈阳性反应。癌变上皮的基底膜PAS反应阴性。原发与继发肿瘤未见显著差别。(3)多数癌巢周围均有完整的网状纤维包绕,但部分呈断裂甚至消失,癌变上皮基底膜的网状纤维则消失。
(1) Changes in DNA, RNA, PAS-positive substances, and reticular fibers in 435 cases of nasopharyngeal carcinoma were observed by histochemical methods. It was found that the content of DNA and RNA in tumor cells was generally higher than that in normal mucosal epithelial cells. DNA content and cell differentiation were inversely proportional to secondary tumors more than primary tumors. RNAs were more common in the cancer nests than in the center. (2) The PA5 response of cancer cells with low differentiation, tumor giant cells, and cancer cells in division was negative; the cancer cells with higher differentiation were positive. The basement membrane of cancerous epithelium has a negative PAS response. There was no significant difference between the primary and secondary tumors. (3) Most of the cancer nests were surrounded by intact reticular fibers, but some of them even ruptured and disappeared. The reticular fibers of the basement membrane of the cancerous epithelium disappeared.