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为显示小白蛋白(Parvalbumin,PV)中间神经元在孤独症脑内的形态变化,更好地理解PV中间神经元在孤独症发病过程中的作用,本研究用免疫组化法观察了孕鼠腹腔注射丙戊酸钠(VPA)和反复冷冻刺激(RCS)法建立的两种孤独症动物模型杏仁体、前额叶皮层和海马区的PV阳性神经元的表达特点。结果显示:两种孤独症模型鼠杏仁体、前额叶皮层和海马区内的PV阳性神经元的胞体形态、大小、突起的长度和密度等与正常对照组(CTL)相比,都发生了不同程度的变化。这些结果提示,PV中间神经元在孤独症的发病过程中发挥重要的作用,它们的改变可能削弱了对孤独症相关的神经环路中锥体神经元的抑制作用。
To show the morphological changes of parvalbumin (PV) interneurons in the autistic brain and to better understand the role of PV interneurons in the pathogenesis of autism, we used immunohistochemistry The expression of PV-positive neurons in amygdala, prefrontal cortex and hippocampus in two autistic animal models established by intraperitoneal injection of sodium valproate (VPA) and repeated freezing stimulation (RCS). The results showed that the cell morphology, size, length and density of PV-positive neurons in the amygdala, prefrontal cortex and hippocampus in both autism models were different from those in normal control group (CTL) The degree of change. These results suggest that PV interneurons play an important role in the pathogenesis of autism and their alterations may impair the inhibition of pyramidal neurons in autism-related neural circuits.