糖尿病肾病（ＤＮ）早期为肾脏体积增大，肾小球容积过多，肾小球滤过率升高；之后肾小球系膜细胞增生，肾小球基底膜增厚，肾小球细胞外基质积聚，最后引起肾小球硬化．并有时表现出肾小球硬化结节形成。糖尿病所致的肾病在国外是导致终末期肾脏疾病的首位病因。近年又提出， Early diabetic nephropathy (DN) increased kidney volume, glomerular volume, glomerular filtration rate increased; after glomerular mesangial cell proliferation, glomerular basement membrane thickening, glomerular extracellular Matrix accumulation, and finally cause glomerular sclerosis. And sometimes shows glomerulosclerosis nodule formation. Diabetic nephropathy is the leading cause of end-stage renal disease in foreign countries. In recent years,