收缩蛋白对Ca2 +敏感性的高低是调节血管平滑肌缩舒功能的重要环节 ,肌球蛋白磷酸酶活性的抑制可增加收缩蛋白对Ca2 +的敏感性。G蛋白、PKC、Rho/Rho激酶均可通过对肌球蛋白磷酸酶活性的抑制来调节血管平滑肌收缩蛋白对Ca2 +的敏感性。G蛋白对肌球蛋白磷酸酶活性的抑制可能与启动血管平滑肌产生收缩有关 ,而PKC通路可能参与了VSM收缩力的稳态上升过程。 The level of contractile protein sensitivity to Ca2 + is an important part of regulating the contractile function of vascular smooth muscle. The inhibition of myosin phosphatase activity can increase the sensitivity of contractile proteins to Ca2 +. G protein, PKC, Rho / Rho kinases can regulate the sensitivity of vascular smooth muscle contraction protein to Ca2 + through inhibition of myosin phosphatase activity. The inhibitory effect of G protein on myosin phosphatase activity may be related to the activation of vascular smooth muscle contraction, and PKC pathway may be involved in the steady-state rise of VSM contractility.