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176例母亲HBsAg 阳性的新生儿分成3组,分别于出生时接种1支和2支乙肝高效价免疫球蛋白(HBIG)及出生时和出生2周时各用1支HBIG。接着在1、2、7个月时接种乙肝疫苗.观察婴儿出现肝功能异常率、抗HBs 阳转率及接种疫苗前外周血抗HBs 浓度.认为出生时和2周时各用1支HBIG 优于其它方案。表明HBIG2支分2次用可发挥更好的保护效果.
One hundred and seventy-six HBsAg-positive mothers were divided into three groups, one HBIG at birth and one HBIG at birth and two weeks after birth. Hepatitis B vaccine was administered at 1, 2, and 7 months later, and abnormal liver function, anti-HBs positive rate and pre-vaccination anti-HBs concentration were observed in infants, and 1 HBIG In other programs. Show HBIG2 two times with branches can play a better protective effect.