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细菌内毒素或脂多糖(LPS)是机体内强烈的免疫调节剂。天然低毒性紫色杆菌LPS 体内处理小鼠,能促进脾细胞的分化、增殖,但降低脾细胞对 Con A 和同种细菌 LPS 的反应性,抑制混合淋巴细胞反应(MLR)和自然杀伤(NK)细胞的活性。LPS 处理供体小鼠还抑制其脾细胞在 F_1 小鼠内诱导的移植物抗宿主反应。应用混合培养方法,在 Con A和 LPS 诱导的淋巴细胞转化反应中分别检测到非特异性抑制细胞活性,但在MLR和NK 活性测定中未发现抑制细胞的存在。上述结果说明 LPS体内抑制T、B 淋巴细胞功能和 NK细胞活性,而这种抑制作用除由抑制细胞介导外,还存在其它尚未明瞭的机理。
Bacterial endotoxins or lipopolysaccharide (LPS) is a strong immune modulator in the body. In vivo treatment of mice with low virulent Lactobacillus flavus LPS can promote the differentiation and proliferation of splenocytes, but reduce the reactivity of splenocytes to Con A and LPS of the same bacteria, and suppress the mixed lymphocyte reaction (MLR) and natural killer (NK) Cell activity. LPS-treated donor mice also inhibited graft-versus-host responses induced by their splenocytes in F1 mice. Mixed cultures were used to detect non-specific cytostatic activity in Con A and LPS-induced lymphocyte transformation reactions, but no suppressor cells were found in MLR and NK activity assays. The above results indicate that LPS inhibits T, B lymphocyte function and NK cell activity in vivo, and this inhibitory effect exists in addition to the inhibition of cell-mediated, there are other mechanisms have not yet been identified.