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发现杂多酸是在水/四氢呋喃或乙醚中三组分一锅煮高产率合成α-胺基膦酸酯的有效催化剂.研究了催化剂用量、反应溶剂、醛和胺的结构对反应的影响.
It has been found that heteropolyacid is an effective catalyst for three-component one-pot synthesis of α-aminophosphonate ester in water / tetrahydrofuran or diethyl ether.The effect of catalyst amount, reaction solvent, aldehyde and amine structure on the reaction was studied.