许多毒素化合物能特异性地改变神经和肌肉细胞产生动作电位的快Na~+电导。这些化合物中重要的一类是脂溶性毒素,如无定型藜芦碱、藜芦属生物碱、箭毒蛀毒素、乌头碱和diter-penoid grayanotoxin。据认为这些毒素分子与Na~+通道同一受点相结合,进而使细胞去极化,这是一种可由河豚毒素(TTX)所阻断或在孵育液中去除Na~+所抑制的去 Many toxin compounds specifically alter fast Na ~ + conductance of nerve and muscle cells to produce action potentials. An important class of these compounds are liposoluble toxins, such as amorphous veratridine, veratrum alkaloids, arrow poison toxins, aconitine and diter-penoid grayanotoxin. It is believed that these toxins bind to the same site of the Na ~ + channel and depolarize the cells, which is blocked by tetrodotoxin (TTX) or inhibited by Na ~ + in the incubation solution