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枳实具有升压、强心和增加心、脑、肾区域血流量等作用而用于治疗休克,效果良好(中草药通讯1974;4:38)。从生药中分离到两个有效单体:对羟福林(Synephrine;Sp)和N-甲基酪胺(N-Methyltyramine;N-mt),含量分别为0.024~0.18%与0.02%左右,并已可人工合成。但天然枳实制剂中二者比例变化较大(从1:1~9:1),致临床疗效不稳定。因此,探索用合成品以恰当的比例代替天然枳实注射液将可能给临床带来稳定的疗效。
Fructus Aurantii has the effect of boosting, strengthening heart and increasing the blood flow in the heart, brain and kidney areas for the treatment of shock and has a good effect (Chinese Herbal Medicine, 1974; 4: 38). Two effective monomers were isolated from crude drugs: Synephrine (Sp) and N-Methyltyramine (N-mt) with the content of 0.024-0.18% and 0.02% Can be synthetic. However, the ratio of the two natural citrus aurantiums varies greatly (from 1: 1 to 9: 1), resulting in unstable clinical efficacy. Therefore, to explore the use of synthetic products in the right proportion of natural citrus aurantium injection will likely bring a stable clinical efficacy.