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目的 观察绝经后妇女不同骨量、骨代谢生化指标及相关因素的变化，以探讨Ⅰ型骨质疏松（ＯＰ）的发病机制。方法 ７５ 例正常绝经后妇女按照宽波段超声衰减（ＢＵＡ） 分成骨量正常组（Ａ 组） 、骨量减少组（Ｂ组） 、骨质疏松组（Ｃ组）。用酶联免疫吸附法（ＥＬＩＳＡ） 法测定各种骨形成与骨吸收的生化标志，用放射免疫分析法（ＲＩＡ） 测定血清中雌二醇（Ｅ２）、卵泡刺激素（ＦＳＨ） 、黄体生成素（ＬＨ） ，此外还测量其身高、体重。结果 Ｂ、Ｃ组分别与Ａ 组相比，骨钙素（ＢＧＰ） 、吡啶酚（ＰＹＤ） 、脱氧吡啶酚（ＤＰＤ） 明显升高，而Ⅰ型胶原羧基端前肽（ＣＩＣＰ）仅在Ｃ组明显升高。Ｃ组分别与Ａ、Ｂ组相比，体重、体重指数（ＢＭＩ） 、Ｅ２ 明显下降，绝经年龄明显提前，且Ｅ２ 在Ｂ组即明显下降，Ｃ组与Ａ 组相比ＦＳＨ 明显升高。直线相关分析显示ＢＵＡ与体重、ＢＭＩ呈正相关（ｒ＝ ０ ．３３３ ，Ｐ＜０ ．０１；ｒ＝０ ．２９１ ，Ｐ＜ ０ ．０５） ，多元逐步回归分析显示ＢＵＡ 与绝经年龄、体重，Ｅ２ 相关（ Ｐ 值分别为０ ．００１ 、０ ．００１ 、０．０１９） 。结论 Ⅰ型ＯＰ的骨形成与骨吸收的生化标志均升高，属高转换型。雌激素下降是其主要发病机制，低体?
Objective To observe the changes of different bone mass, biochemical indexes of bone metabolism and related factors in postmenopausal women to explore the pathogenesis of type Ⅰ osteoporosis (OP). Methods Seventy - five normal postmenopausal women were divided into normal bone mass group (A group), osteopenia group (B group) and osteoporosis group (C group) according to broad band ultrasonic attenuation (BUA). The biochemical markers of bone formation and bone resorption were determined by enzyme linked immunosorbent assay (ELISA). Serum estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), in addition to measuring its height and weight. Results BGP, PYD and DPD were significantly increased in groups B and C compared with those in group A, while CICP was only found in group C Significantly increased. Body weight, body mass index (BMI) and E2 decreased significantly in group C compared with those in group A and B, and the age of menopause was significantly advanced. E2 decreased significantly in group B, and FSH increased significantly in group C compared with group A. Linear correlation analysis showed that BUA was positively correlated with body weight and BMI (r = 0.333, P <0.01; r = 0.291, P <0.05). Multiple stepwise regression analysis showed that BUA was positively correlated with age, weight, (P = 0.001, 0.001, 0.019, respectively). Conclusion The type Ⅰ OP bone formation and bone resorption biochemical markers were elevated, is a high conversion type. Estrogen decline is its main pathogenesis, low body?