大肠癌为我国常见恶性肿瘤之一，其发病率呈逐年上升趋势。但其总的治疗效果仍不理想，复发和死亡屡有所见。因此如何提高治疗效果乃当务之急。随着分子生物学理论和技术的发展，对大肠癌基因突变和表达的研究也日益广泛和深入。ｐ５３基因突变被认为是腺瘤－腺癌序列演变中的 Colorectal cancer is one of the common malignancies in China, and its incidence rate is increasing year by year. However, its overall therapeutic effect is still not satisfactory, and recurrence and death have been seen repeatedly. Therefore, how to improve the therapeutic effect is a top priority. With the development of molecular biology theory and technology, the study of gene mutation and expression in colorectal cancer has become increasingly widespread and in-depth. Mutations in p53 gene are thought to be involved in the evolution of adenoma-adenocarcinoma sequences.