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[目的]探讨抑癌基因 p16与涎腺腺样囊性癌的发生发展的关系。[方法]采用免疫组织化学法检测30例腺样囊性癌中p16基因表达情况。[结果]腺样囊性癌组织中阳性表达率为76 6 % ,p16蛋白阳性率在腺样囊性癌的腺样型、管状型、混合型、实体型中分别为90 %、100 %、75 %、42 9 % ,显示 p16蛋白表达阳性率随恶性程度的上升而降低 ,p16阳性与阴性之间的5年生存率则无明显差异。[结论]抑癌基因 p16的表达与肿瘤的病理类型有关 ,而腺样囊性癌预后好于其它肿瘤可能与其 p16缺失少有关。
[Objective] To investigate the relationship between tumor suppressor gene p16 and the occurrence and development of adenoid cystic carcinoma of salivary glands. [Methods] The expression of p16 gene in adenoid cystic carcinoma was detected by immunohistochemistry. [Results] The positive expression rate of adenoid cystic carcinoma was 76.6%, and the positive rate of p16 protein was 90%, 100% in adenoid, tubular, mixed, and solid type of adenoid cystic carcinoma, respectively. 75 % and 42 9 % showed that the positive rate of p16 protein expression decreased with the increase of malignant degree. There was no significant difference in the 5-year survival rate between p16 positive and negative. [Conclusion] The expression of tumor suppressor gene p16 is related to the pathological type of tumor, but the prognosis of adenoid cystic carcinoma is better than that of other tumors and may be related to its less p16 deletion.